The immediate take home is thatthis blend of traditional herbs appears to mimic the effects of statins on thecholesterol mix. That alone makes it anattractive solution to those needing to control cholesterol.
We add this piece to provide theinformation. Everyone needs to beproactive in supporting their health. Recall medical advice is terribly constrained by having limited data aboutyou. A doctor has to be lucky to gainanything in a ten minute consultation. You, on the other hand have the rest of your life to get it right and tothen find a doctor who will listen to you.
People who beat the odds do takecharge of their own health and do need information such as this.
Four herb mix in Stem Cell 100 with some screening from Genescient
MAY 07, 2011
Survival curve for fruitflies given the fourherb mixture versus controls
Genescient- Stem Cell 100 have a slightly updated version of their hplus magazine article from Jan, 2011
2. From Indian Ayurvedic medicinal traditionan anti-diabetic herb, Pterocarpus marsupium (Indian keno tree bark)
3. Pine Bark Proanthocyanidins was pickedfrom wide-spectrum herbalextracts in Western herbal medicine.
4. L-theanine (also known asgamma-glutamylethylamide, or 5-N-ethyl-glutamine) is a uncommon amino acidfound preferentially in green tea.
Repeating my position
Stem Cell 100 is not proven. Genescient has long lived fruit flies. The flieslive 4-5 times longer than regular flies. This is not in dispute. They then usethose and other flies to try and test material that does not require FDAapproval. The reason being is that they do not want to wait 5-15 years to getsomething approved. They can look at herbs and drugs that are no longer underpatent. Based on this they have screened a set of material which happens tobe mostly a mix of different herbs.You don't have to try it. I see no downside in trying it. Basically I am payingto join a clinical trial (phase 2, but since they are herbs need noclinical trial) of herbs which are known to be not dangerous (phase 1 trialsprove safety) but are not proven to be effective. The approach that some wouldadvocate are for -absolute proof- with appropriate animal models and then humantrials is the 12-30 year method which results in pills that are $10-20 per pillinitially. If Stem Cell 100 raises my good cholesterol levels and lowers badcholesterol then I have paid for some pretty good statins at somewhat lowercost (unless I could get Statins covered under a medical plan).
I am not telling you to take it and I am not inflating their claims. I am alsosaying if people want more certain life extension and want to donate wheretheir money can make a difference should donate to SENS and to Robert Freitasvia IMM. The rejuvenation that would result if they are successful would be farmore obvious life extension. The Genescient approach will be fortunate toimprove the odds of adding a few real years of life extension.
There have been studies of the components that are in Stem Cell 100 and two ofthe components have been used for many hundreds to thousands of years in
The survival curve for fruit flies that were bred for longevity
Astragulus membranaceus
In Chinese traditional medicine, Astragalus membranaceus (Huang Qi)appeared to be the best Chinese herb becauseof its many traditional uses and studies demonstrating stem cell activation andinhibition of mTOR. The mTOR inhibition has extended mouse mean lifespan by33%. In traditional Chinese medicine, astragalus is considered a true tonicthat can strengthen debilitated patients and increase resistance to disease ingeneral. Modern herbal treatments with Astragalus membranaceus root (often inconcert with other herbs) are partly based on clinical trials showing benefitsin strengthening immune function during viral (e.g. chronic hepatitis) orbacterial infection or in those individuals undergoing dialysis for kidneyfailure. Clinical trials at the US National Cancer Institute and other worldcenters have indicated that Astragalus can strengthen immunity and improvesurvival in some individuals with cancer.
Pterocarpus marsupium
Crude extracts of Pterocarpus marsupium (Indian keno tree) barknaturally have high concentrations of pterostilbene (one of three resveratrolanalogs in Pterocarpus) and have been used as a traditional herbal treatmentfor diabetes in India
As an herbal medicine, Pterocarpus marsupium is popular in
Pine Bark Proanthocyanidins
Pine Bark Proanthocyanidins stand out as the best wide-spectrum herbal extracts inWestern herbal medicine. Proanthocyanidins are polymer chains of flavonoids(flavan-3-ols) that were discovered by Jacques Masquelier in 1948 and have beena major therapeutic supplement in Europe sincethe 1980’s. Most of the research and commercial success with proanthocyanidinshas involved extracts of a French maritime pine bark called Pycnogenol (65 to75% proanthocyanidins) and various grape seed extracts (80-90%proanthocyanidins).
One interesting claim of health benefits of proanthocyanidins is the hypothesisthat they are responsible for the “French Paradox”, wherein the French tend tohave much reduced rates of cardiovascular disease compared to other Westerncountries on a high-fat diet because of their high intake of red wine made withgrapes. Besides their possible cardiovascular effects, Oligo-Proanthocyanidins(OPCs as attached units of proanthocyanidins are called) are known to have manyother health benefits. For example, OPCs stabilize collagen and elastin, whichare two essential proteins in connective tissues including blood vessels,muscles, and skin. OPCs are reported to reduce genetic mutations, so they havesome anticancer benefits. OPCs have also been shown in clinical trials topromote blood flow and endothelial nitric oxide while reducing edema, capillaryfragility, and damage caused by pollution, toxins, and cigarette smoke. Thesediverse health benefits make Pine Bark proanthocyanidins another perfectcandidate to combine with wide-spectrum herbal extracts of Astragalusmembranaceus and Pterocarpus marsupium bark.
L-theanine
L-theanine (also known as gamma-glutamylethylamide, or 5-N-ethyl-glutamine)is a uncommon amino acid found preferentially in green tea. Theanine is ananalog of glutamine and glutamate and can cross the blood-brain barrier as apotential neuroprotective agent. Among its psychoactive properties, theanine isreported to reduce mental stress and improved cognition and mood via itsbinding to the GABA brain receptors in the parasympathetic nervous system.Thus, theanine appears to increase the overall level of the brain inhibitorytransmitter GABA and is reported to promote alpha wave production in the brain.Theanine also increases brain dopamine concentrations and has significantaffinities for the AMPA and NMDA receptors. The NMDA receptors help controlmemory and synaptic plasticity. Theanine may also have positive effects on serotoninlevels to promote restful sleep. In rats, theanine is neuroprotective. All ofthese neuroprotective properties of L-theanine make it a strong complementaryaddition to the three essential core herbs of the herbal mix. We named thefinal 4-herb mix Stem Cell 100, because of its positive effects on adult stemcells and have filed a patent application on this wide-spectrum nutraceutical.
Pilot Field Trial on Human Volunteers
A small clinical field trial using Stem Cell 100 for a period of fourmonths was carried out with healthy volunteers that had cholesterol and bloodpressure readings in the normal range. Cholesterol tests and blood pressuremonitoring were performed before and after treatment with StemCell 100 to seeif the treatment changed cholesterol or blood pressure profiles. In the labtesting, liver function and blood chemistry were the same before and aftertreatment for all participants, but there was a non-significant trend towardreductions in total cholesterol, LDL, and triglycerides with the herbaltreatment. These trends would likely have been significant if a larger samplesize were used.
The biggest surprise was the relatively large increases in HDL (goodcholesterol) in all test subjects including those individuals who were takingstatins. The mean HDL was 58 mg/dL before treatment (range of 44 to 73 mg/dL)and was a mean of 72 mg/dL after treatment (range of 58 to 82 mg/dL). Treatmentwith Stem Cell 100 thus increased HDL by a mean of 13 mg/dL (SD = 1.29 and P =0.006) or 22% increase in the treated volunteers. Although this was not aplacebo controlled trial, this mean HDL increase is much larger than anyexpected placebo effect and is likely to be significant despite the lack ofa placebo control.
We also checked most volunteers before and after Stem Cell 100 treatment forchanges in blood pressure. While some individuals were concurrently takingantihypertensive drugs, all volunteers initially tested in the normal range forboth systolic (mean = 122 mm Hg with a range of 102 to 133) and diastolic (mean= 79 mm Hg with a range of 70 – 88) blood pressure. After 4 weeks on Stem Cell100, systolic levels fell to a mean of 112 mm Hg (range of 99 to 121 mg Hg) anddiastolic blood pressure fell to a mean of 69.5 mm Hg (range of 61 to 78 mmHg). These data translate into a highly significant mean systolic loss of 9.5mm Hg (P less than 0.0003), while diastolic blood pressure had a mean losstrend of 12 mm Hg (P = 0.092). If the sample size were larger, we believe thatdiastolic blood pressure would also have dropped significantly.
Since this clinical field trial gave such unexpectedly favorable results, wewish to verify these data via a double-blind, placebo-controlled clinical trialusing Stem Cell 100 and these indicators. Of course, proper clinical trials areexpensive, so sufficient funding will have to be secured before such clinicaltrials can be started. If you are planning a clinical trial with any of theseblood markers or age related-disease endpoints, Stem Cell 100 might be a goodadjunct to other therapies that are to be tested.
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