This one more plausible strategythat looks to at least suppress cancer growth, but unable to actually eliminatethe disease entirely. Thus antiMetastasis strategys would also have to be implemented.
We have heard nothing more on thenanogold protocol out of MIT yet, but that promises to be the real anti cancerbullet. It works by preferentially slippinginto cancer cells were they can be heated by a simple application of radiowaves. It actually works and it is realnano surgery.
In this case, we are looking fordrug pathways that do the job and this will likely produce something of use.
Scientists discover a way to kill off tumors in cancer treatmentbreakthrough
Scientists from the School of Pharmacy at Queen's University Belfastand Almac Discovery Ltd have developed a new treatment for cancer which ratherthan attacking tumours directly, prevents the growth of new blood vessels intumours, starving them of oxygen and nutrients, thereby preventing theirgrowth.
Targeting tumour blood vessels is not a new concept, however, this drugattacks the blood vessels using an entirely different pathway and thereforecould be useful for treating tumours which don't respond to or which areresistant to current therapies of this type.
Professor Tracy Robson and her research team at Queen's, incollaboration with researchers at Almac Discovery, developed a new drug todisrupt the tumour blood supply. They have demonstrated that this leads tohighly effective inhibition of tumour growth in a number of models as reportedthis month in Clinical Cancer Research, a journal of the AmericanAssociation for Cancer Research. Almac Discovery is developing the drugcandidate and expects to start clinical trials within the next year.
Professor Tracy Robson from the School of Pharmacy at Queen's explains: "By understanding the anti-angiogenic potential ofthe natural protein, FKBPL, we have been able to develop small peptide-baseddrugs that could be delivered to prevent tumour growth by cutting off theirblood supply. This is highly effective in models of prostate and breast cancer.
"However, this also has the potential for the treatment of anysolid tumour and we're excited about continuing to work with Almac Discovery asthis drug enters clinical trials."
Dr Stephen Barr, President and Managing Director of Almac Discoverysaid: "This is a first class example of a collaboration between auniversity and industry to produce a novel approach to cancer therapy that hasa real chance of helping patients".
The Almac Discovery / Queen's University drug is currently undergoingpreclinical development and may provide a first-in-class therapy for targetingtumour angiogenesis by an entirely different pathway to those agents currently approved.
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For media enquiries please contact Claire O'Callaghan on 00 44 (0)2890975391 / 07814422572 or c.ocallaghan@qub.ac.uk
Contact: Claire O'Callaghan
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